The world’s biggest and oldest living trees are disappearing and will never be replaced, according to a new review of global ecosystems.

The study, published last week in the journal Science, found that trees between 100 and 300 years old are dying off at an alarming rate.

“What we’re seeing is a global phenomenon,” said the paper’s lead author, ecologist David Lindenmayer of Australian National University. “There are different sets of drivers—it might be fire, logging, drought, disease—but they all lead to basically the same outcome.”

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